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SGR-1505 is under clinical development by and currently in Phase I for Burkitt Lymphoma. According to GlobalData, Phase I drugs for Burkitt Lymphoma have a 68% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. SGR-1505 overview SGR-1505 is under development for the treatment of BTK-resistant, refractory or relapsed B-cell non-Hodgkin lymphoma, diffuse large B-cell lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma (MCL), Waldenstrom macroglobulinemia, MALT lymphoma, follicular lymphoma, Burkitt lymphoma, plasmablastic lymphoma, high-grade B-cell lymphoma, primary cutaneous follicle center lymphoma, primary effusion lymphoma, primary mediastinal large B cell lymphoma, T-cell/histiocyte rich lymphoma, ALK-positive large B-cell lymphoma, primary cutaneous diffuse large B-cell lymphoma splenic marginal zone lymphoma, nodal marginal zone lymphoma, HHV8-positive DLBCL and duodenal-type follicular lymphoma. It is administered through oral route in the form of tablet. The drug candidate acts by oncogenic activation of nuclear factor-kappa B which acts by targeting MALT1 activity. It is developed based on the artificial intelligence (AI) technology. Schrodinger overview is a healthcare technology company that provides software solutions for drug discovery. The company offers a computational platform designed with predictive modeling, data analytics and collaboration applicable to molecular discovery. Its pipeline products include SGR-1505 (MALT1) against non-Hodgkin’s lymphoma, SGR-2921 (CDC7) to treat hematological cancers and solid tumors and SGR-3515 (Wee1) for gynecological cancers, and LRRK2 for Neurology and SOS1 for cancers and others. ‘s other products include small molecule products, biological drug discovery and material science products. It provides training, documentation and support services. The company operates through offices in the US, Germany, Japan, Ireland, the UK, India, China and South Korea. is headquartered in New York City, New York, the US. For a complete picture of SGR-1505’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .Cue the William Regal, because it is time for: WarGames. Held every year since 1987, WWE Survivor Series will be Saturday night with five bouts scheduled to take place, headlined by the match stipulation that has become synonymous with the event. There will be two WarGames matches, including the one between the new Bloodline vs. old Bloodline that much of the WWE Universe is eagerly waiting for. Three championships will also be on the line in the final main roster premium live event of the year as the road to WrestleMania approaches when 2025 begins. Follow USA TODAY Sports for all the highlights and analysis for Survivor Series 2024: When is Survivor Series: WarGames 2024? Survivor Series: WarGames 2024 is Saturday, Nov. 30 at 6 p.m. ET. Where is Survivor Series: WarGames 2024? Survivor Series: WarGames 2024 will take place at Rogers Arena in Vancouver, Canada. It will be the first premium live event to take place in Vancouver since 1998. How to watch Survivor Series: WarGames 2024: TV channel, streaming The event can be streamed on Peacock , but you must have their premium or premium-plus subscription to watch. Internationally, it will be available on WWE Network. Is there a Survivor Series: WarGames 2024 preshow? Yes. The preshow for Survivor Series: WarGames will begin at 4 p.m. ET and will air on Peacock, WWE's YouTube and social media accounts. Survivor Series: WarGames 2024 match card Matches not in order

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ALBANY, N.Y. — Christian Brothers Academy will honor and celebrate former head coach David Doemel ’71 with a special court dedication ceremony on Friday, Dec. 27, at 6:30 p.m. in the Ned McGraw Gymnasium, before the start of the Holiday Basketball Tournament Varsity game. “Christian Brothers Academy has been honored to have David Doemel ’71 as part of its faculty and coaching staff for more than 40 years,” wrote a spokesperson for the CBA athletic department, via press release, on Thursday. “Coach Doemel ’71 has played an integral role in the success of Christian Brothers Academy for over half a century. His positive impact on thousands of students, players, and families will forever be remembered; and will have a presence in CBA history as one of our winningest coaches.” Doemel finished his varsity basketball career with 415 victories, seven Section 2 titles, and the only basketball State Championship in school history. In addition, with 248 varsity baseball victories, Doemel is second only to Jim Pedlow ’60 in career baseball wins. No one in the history of CBA has more combined victories at all levels than Dave Doemel. CBA will unveil the name of the basketball court; which will be known as ‘The Dave Doemel ’71 Court’, in front of Dave’s family, friends, colleagues, former students, alumni, and the entire CBA community. The celebration will continue with a reception in the CBA cafeteria, post-ceremony. The Brothers are 2-1 in 2024-25 under new, first-year head coach and program alum Galal Cancer. They’ll take on Chaminade (0-2) at 7 p.m., marking a second straight matchup against a New York Catholic High School League opponent.

The Observer view on the disturbing prevalence of child sexual abuse in the home | Observer editorial

Pollies, peace deals, and the unravelling of a billionaire: The WA civil court rows that dominated 2024

Opinion: President Jimmy Carter made wrong decision to call for a boycott of 1980 Moscow OlympicsLauren Betts, No. 5 UCLA get past No. 17 Louisville

MiLaysia Fulwiley put up 23 points and Chloe Kitts scored 19 points and grabbed 10 rebounds as No. 1 South Carolina routed Coppin State 92-60 on Thursday in Columbia, S.C. Te-Hina Paopao added 13 points and five assists for the Gamecocks (3-0). Joyce Edwards and Maryam Dauda each contributed 10 points for South Carolina, which shot 51.5 percent from the floor and compiled a 51-23 rebounding edge. Laila Lawrence scored 20 points and Angel Jones notched 17 for the Eagles (2-2). No. 8 Iowa State 80, St. Thomas (Minn.) 47 Audi Crooks shot 12-for-17 en route to 26 points and pulled down a game-high eight rebounds as the Cyclones topped the Tommies in Ames, Iowa. Sydney Harris registered 13 points while Addy Brown had 10 for Iowa State (4-0). Amber Scalia's 11 points paced St. Thomas (3-1). No. 10 Kansas State 86, Creighton 68 Ayoka Lee powered for 28 points in 16 minutes as the Wildcats topped the Bluejays in Manhattan, Kan. Kansas State (3-0) jumped out to a 22-9 lead after one quarter and rolled to the win. Temira Poindexter and Serena Sundell each had 12 points for the Wildcats, with Sundell adding eight assists and seven rebounds. Kennedy Townsend scored 16 points, Morgan Maly added 15 and Kiani Lockett had 11 for Creighton (1-2). No. 13 North Carolina State 79, Kent State 51 After leading by just five points at halftime, the Wolfpack expanded the lead in the third quarter and then cruised in the fourth to beat the Golden Flashes in Raleigh, N.C. Aziaha James paced NC State (2-1) with 20 points and nine rebounds, and Zamareya Jones scored 16 points. Kent State (1-2) got 17 points and eight rebounds from Bridget Dunn, plus 15 points from Jenna Batsch. No. 16 Duke 84, Dayton 49 Six players logged double-figure point totals for the Blue Devils in the one-sided victory over the Flyers at Durham, N.C. Ten players hit the scoresheet overall for Duke (3-1), which got a team-high 17 points from Jordan Wood. Toby Fournier added 15 points. Ivy Wolf had 14 points and seven rebounds, and Ajok Madol contributed 12 points for Dayton (2-1), which shot 32.1 percent from the floor and committed 24 turnovers. No. 17 Baylor 104, East Texas A&M 55 Darianna Littlepage-Buggs recorded 22 points and 11 rebounds as the Bears nearly doubled up the Lions in Waco, Texas. Aaronette Vonleh (18 points, 11 rebounds) also had a double-double for Baylor (2-1). Cora Horvath was the top offensive threat for East Texas A&M (2-2) with 22 points. No. 19 Ole Miss 80, Delaware State 42 Starr Jacobs hit 8 of 10 shots from the floor and scored 18 points as the Rebels pulled away from the Hornets in Dover, Del. Madison Scott, Kennedy Todd-Williams and Sira Thienou each put up 13 points for Ole Miss (2-1), which outscored Delaware State 43-21 in the second half. The Hornets (1-3) were led by Kiarra Mcelrath with 13 points and Mahogany Cottingham with 10. No. 22 Alabama 88, Alcorn State 59 Essence Cody amassed 18 points, eight rebounds and four blocks as the Crimson Tide thrashed the Lady Braves in Tuscaloosa, Ala. Aaliyah Nye scored 17 points, Eris Lester had 15 and seven rebounds, and Sarah Ashlee Barker chipped in with 14 points and three steals for the Crimson Tide (5-0). Destiny Brown was the only player in double figures for Alcorn State (1-3), scoring 12 points. No. 23 Illinois 84, Eastern Illinois 37 Reserve Jasmine Brown-Hagger hit 10 of 15 shots scored 23 points to lead the Fighting Illini to a laugher against the Panthers in Champaign, Ill. Gretchen Dolan added 13 points, Kendall Bostic produced 11 points and 12 rebounds and Adalia McKenzie also had 11 points for Illinois (3-0). Jayda Johnston finished with eight points for Eastern Illinois (0-3). --Field Level Media